BandView®

What is G-Banding and Karyotyping?

G-banding is the treatment of chromosomes in the metaphase stage with trypsin (to partially digest the protein) and stain them with Giemsa. Each homologous chromosome pair has a unique pattern of g-bands, enabling recognition of particular chromosomes

A karyotype is an organized profile of a Human, Plant and Animal chromosomes. In a karyotype, chromosomes are arranged and numbered by size, from largest to smallest. This arrangement helps scientists quickly identify chromosomal alterations that may result in a genetic disorder.

BandView

BandView® is Applied Spectral Imaging's fully-automated image acquisition and analysis system for Karyotyping. You can either run it as an independent Karyotyping system and upgrade later to FISHView or HISKY or integrate it into your CytoLabView system. With the assistance of user input, ASI has created a user friendly, and accurate Karyotyping system.

 

 

BandView brings you:

  • Powerful automated karyotyping tools
  • Superb image resolution
  • Advanced enhancement algorithms
  • Convenient image gallery to scan metaphases and karyotypes
  • Multi-language database Case Data Manager (CDM) with link and reports
  • Access to patient data statistics according to the parameters you choose
  • Seamless upgrade to HISKY and FISHView (no need to change the camera, database or microscope)
  • No loss of original image data during analysis
  • Automated classification of brightfield or fluorescently stained metaphases
  • Proprietary background subtraction enables automatic chromosome segmentation on sub-optimal metaphases
  • Easy separation of touching and overlapping chromosomes
  • Chromosome straightening without losing original image data
  • ISCN 2005 Ideograms for 300,400, 550, 700 and 850 band resolution
  • Ideogram editor to display breakpoints and translocations in the ideogram
  • Robust same-case comparison tool to compare chromosomes in the same pair
  • Cross-application comparison tool to compare band, FISH and HISKY analysis
  • Dynamic karyotype table to fit any number of chromosomes

 

Acquisition Features - Image Capture

  • High resolution images with 12-bit digital CCD-camera (1280x1024 pixels)

  • Live-view image display throughout image acquisition

  • User defined Region of Interest (ROI)

  • Extremely low dark noise allowing for long exposure times

  • Automatic exposure for brightfield, phase contrast and epi-fluorescence

  • Easy graphic user interface for quick image acquisition

  • Convenient image gallery to preview images before analysis

  • MergeView - Unlimited joining of frames to create one image from multiple images of a sparse metaphase

 

Enhance Images

  • Advanced Contrast both manual and automatic

  • Automatic background correction which accurately resolves non-uniform microscope illumination to allow optimized segmentation

  • Save and apply customized settings, such as the Band Enhancement level to each new image

  • 10-level enhancement of fine band detail in brightfield and fluorescence

  • Advanced color control for precise brightness and contrast adjustments

  • Restore original contrast and brightness in one click

 

Analysis Features - Robust Image Analysis

Smart tools active both in Metaphase and Karyotype status

  • Single Magic Tool for all segmentation requirements including crossed or adjacent chromosomes

  • Centromere Alignment

  • Multi color display to validate correct segmentation

  • Fully dynamic Karyotype table with no limit to the number of chromosomes and markers

  • User defined Karyotype table with capability to change the distance and height between chromosomes

  • Manual Counting for Chromosomes with Index

  • Fast Semi-Automatic Counting of Chromosomes

  • Multiple Undo for any operation.

  • Zoom up to 1000% in Metaphase as well as Karyotype table

  • Single window with Multiple Image Gallery for up to 24 Images (combined Karyotype & Metaphase image report generation)

  • Fully upgradeable for Multi-Species Mouse, Rat, Hamster, etc.

  • Compare same-case and multi-case metaphases and/or karyotypes

  • Chromosome comparison. Same case and multi-case options Enables comparing of results of G-band, FISH, HISKY and other applications within a single report (i.e. G-band staining alongside HISKY and FISH stained chromosomes)

 

User-friendly Reports and Comparison Tables

  • Flexible report generation to include any combination of data, including metaphase with case data reports, physician reports, analyzed cells report and statistics summary report

  • On-the-fly generation of case statistics reports according to the parameters you set

  • Compatibility with any printer with a Windows XP driver

  • Multi-language capabilities for the user interface and reports

 

Manage Cases

  • Compare same-case and multi-case metaphases and/or karyotypes
  • Chromosome comparison. Same case and multi-case options. Enables comparing of results of G-band, FISH, HISKY and other applications within a single report. (i.e. G-band staining alongside HISKY and FISH stained chromosomes)
  • Compare Karyotype lines between cells with immediate correction from any chromosome from any cell
  • Powerful search utility that can filter by any field, including text strings
  • Multi-language capabilities for the user interface and reports
  • Archiving to any storage media
  • Convenient image gallery to spot cases by metaphase or karyotype
  • Immediate access to all patient data in one mouse click
  • Network support for multiple systems and workstations

 Installation and Support

  • Detailed user manuals and extensive on-line help.
  • Free phone support for a year from system installation.
  • One-year warranty for the system and a three-year warranty for the computer.

http://www.spectral-imaging.com/BandView.asp

 

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